Oxidation of the bupropion side chain results in the formation of a glycine conjugate of metachlorobenzoic acid, which is then excreted as the major urinary metabolite. Following oral administration of 200 mg of 14C-bupropion in humans, 87% and 10% of the radioactive dose were recovered in the urine and feces, respectively. However, the fraction of the oral dose of bupropion excreted unchanged was only 0.5%, a finding consistent with the extensive metabolism of bupropion. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
Missed Dose
Your doctor may recommend Wellbutrin if the benefits of treatment outweigh the risks of side effects. Keep reading to learn about other possible mild and serious side effects of this drug. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Weight gain
But studies of people taking Wellbutrin XL for seasonal affective disorder (SAD) have reported flatulence, which wasn’t reported in studies of Wellbutrin SR. But if you have symptoms that are ongoing or bothersome, talk with your doctor or pharmacist. You should not change your dose or stop using BuPROPion (Eqv-Wellbutrin SR) suddenly, unless you have a seizure while taking this medicine.